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KMID : 0363620070280020044
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 2 p.44 ~ p.53
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Neuroprotective Effects of Hyulbuchookau-tang(血府逐瘀湯) on Global Cerebral Ischemia of the Rats
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Cho Eun-Hee
Kim Young-Kyun
Kwon Jung-Nam
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Abstract
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Objectives: This study examined the neuroprotective effect of Hyulbuchookau-tang (血府逐瘀湯, HBCAT) against neural damage following global cerebral infarction.
Methods: Sprague-Dawley rats were induced with global cerebral infarction by occlusion of the bilateral common carotid artery with hypotension (CCAO). The rats were divided into 3 groups. We treated extract of HBCAT to one group after operation (sample group), one group wasn’t induced with ischemic damage after operation (sham group), and one group was induced with ischemic damage after operation (control group) but not treated. We observed neurological scores and cresyl violet-stained hippocampus CAl area, TUNEL-positive neurons, and Bax-positive neurons in brain regions.
Results: HBCAT treatment after CCAO increased pyramidal neurons in CAl hippocampus induced by CCAO. HBCAT treatment after CCAO reduced Bax-positive neurons in CAl hippocampus of brain regions induced by CCAO. HBCAT treatment after CCAO wasn’t effective for HSP70-positive neurons in CAl hippocampus induced by CCAO.
Conclusion: These results suggest that HBCAT has a neuroprotective effect against global cerebral ischemia.
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KEYWORD
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Hyulbuchookau-tang(血府逐瘀湯, HBCAT), common carotid artery occlusion(CCAO), neuroprotective effect, global cerebral infarction
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